HB Tsim Cov Txheej Txheem Tshiab rau Cov Qauv Siv Tshuaj lom neeg ntawm ICL

Imperial College London (ICL) yog tus thawj coj ntawm kev tshawb fawb tshawb fawb thiab, los ntawm Lub Tsev Haujlwm Saib Xyuas Kev Tiv Thaiv thiab Kab Mob thiab Lub Tsev Haujlwm Saib Xyuas Kev Tshawb Fawb, nws cov kev tshawb fawb nthuav tawm los ntawm rheumatology thiab hematology mus rau dementia, Parkinson's disease thiab mob qog noj ntshav hauv hlwb. Kev tswj cov kev tshawb fawb sib txawv no yuav tsum muaj cov chaw nyob hauv lub xeev, tshwj xeeb tshaj yog rau kev khaws cia cov qauv tshuaj lom neeg tseem ceeb. Neil Galloway Phillipps, Senior Lab Manager rau ob lub tuam tsev, tau lees paub qhov xav tau kom muaj txiaj ntsig zoo dua thiab muaj txiaj ntsig zoo khaws cia cov tshuaj cryogenic.

ICL xav tau

1.Lub peev xwm siab, sib sau ua kua nitrogen cia system

2.Txo nitrogen noj thiab cov nqi ua haujlwm

3.Txhim kho cov qauv kev ruaj ntseg thiab kev ua raws cai

4.Kev nyab xeeb thiab siv tau zoo dua rau cov kws tshawb fawb

5.Txoj kev daws teeb meem zoo los txhawb cov phiaj xwm ntsuab

Cov kev sib tw

ICL Lub Tsev Haujlwm Saib Xyuas Kev Tiv Thaiv Kab Mob yav dhau los tau tso siab rau 13 cais cov kua nitrogen zoo li qub (LN₂) tso tsheb hlau luam los khaws cov qauv kuaj sim, satellite cell thiab cov kab lis kev cai ntawm tes. Cov txheej txheem fragmented no tau siv sijhawm los tswj, yuav tsum tau saib xyuas tas li thiab rov ua dua tshiab.

Neil piav qhia tias "Kev ntim 13 lub tank siv sijhawm ntau, thiab kev taug qab txhua yam tau dhau los ua nyuaj," Neil piav qhia. "Nws yog ib qho kev sib tw logistical, thiab peb xav tau txoj hauv kev zoo dua los tswj peb qhov chaw cia."

Tus nqi ntawm kev tuav ntau lub tank yog lwm qhov kev txhawj xeeb. LN₂kev siv tau siab, ua rau muaj kev nce nqi ua haujlwm. Nyob rau tib lub sijhawm, kev cuam tshuam ib puag ncig ntawm kev xa khoom nitrogen nquag yog qhov tsis txaus ntseeg nrog lub chaw kuaj mob kev cog lus rau kev ruaj khov. Neil tau sau tseg tias "Peb tau ua haujlwm rau ntau yam khoom plig txhawb nqa, thiab peb paub tias txo peb cov kev siv nitrogen yuav ua rau muaj qhov sib txawv loj," Neil tau sau tseg.

Kev ruaj ntseg thiab kev ua raws li qhov tseem ceeb tseem ceeb. Nrog ntau lub tso tsheb hlau luam sib kis thoob plaws thaj chaw sib txawv, kev taug qab nkag mus thiab tswj cov ntaub ntawv hloov tshiab tau nyuaj. "Nws yog ib qho tseem ceeb uas peb paub tseeb tias leej twg nkag mus rau cov qauv, thiab txhua yam yog khaws cia kom raug raws li Human Tissue Authority (HTA) cov cai," Neil ntxiv. "Peb cov txheej txheem qub tsis ua kom yooj yim."

Txoj kev daws teeb meem

ICL twb muaj ntau yam khoom siv los ntawm Haier Biomedical - ncua kev cia txias, khoom siv roj ntsha kev nyab xeeb, CO₂incubators thiab centrifuges - txhim kho kev ntseeg siab hauv lub tuam txhab cov kev daws teeb meem.

Neil thiab nws pab neeg yog li ntawd tau mus cuag Haier Biomedical los pab daws cov teeb meem tshiab no, txhim kho lub peev xwm loj CryoBio 43 LN₂biobank los sib sau tag nrho 13 lub tso tsheb hlau luam zoo li qub rau hauv ib qho kev ua haujlwm siab. Qhov kev hloov pauv tau zoo sib xws, nrog Haier pab pawg tswj hwm kev teeb tsa thiab cob qhia cov neeg ua haujlwm hauv chav kuaj. Lub kaw lus tshiab tau qhib rau hauv LN uas twb muaj lawm₂qhov chaw nrog tsuas yog hloov me me. Nrog cov txheej txheem tshiab nyob rau hauv qhov chaw, cov qauv khaws cia thiab kev tswj hwm tau ua haujlwm tau zoo dua. Neil tau sau tseg tias "Ib qho ntawm qhov txiaj ntsig tsis tau xav txog yog qhov chaw peb tau txais ntau npaum li cas," "Nrog tag nrho cov qub tso tsheb hlau luam tshem tawm, tam sim no peb muaj ntau chav hauv chav kuaj rau lwm yam khoom siv."

Kev hloov mus rau vapour-theem cia tau txhim kho kev nyab xeeb thiab yooj yim ntawm kev siv. "Yav tas los, txhua zaus peb rub lub khib tawm ntawm cov kua-theem tank, nws yuav poob nrog nitrogen, uas yog ib txwm muaj kev txhawj xeeb txog kev nyab xeeb. Tam sim no, nrog vapour-theem cia, nws muaj ntau yam huv thiab nyab xeeb dua los coj cov qauv. Lub biometric access system kuj tseem muaj zog vim tias peb tuaj yeem taug qab kev ruaj ntseg thiab ua raws.

Neil thiab nws pab neeg pom cov kab ke siv tau yooj yim, nrog Haier txoj kev cob qhia ua rau lawv sai sai rau cov neeg siv khoom kawg.

Ib qho kev npaj txhij txog tab sis zoo siab tos txais yog cov kauj ruam rov qab tsis siv neeg, uas ua rau nkag mus rau lub tank yooj yim dua. "Nrog rau cov tso tsheb hlau luam yav dhau los, cov kws tshawb fawb feem ntau yuav tsum tau nqa cov khoom tawm tag nrho. Txawm hais tias lub tank tshiab siab dua, cov kauj ruam xa mus rau ntawm lub pob khawm, ua rau ntxiv lossis tshem cov qauv yooj yim dua los tswj," Neil hais.

Khaws cov qauv zoo

Cov qauv khaws cia hauv ICL's cryogenic facility yog qhov tseem ceeb rau kev tshawb fawb tsis tu ncua. Neil tau hais tias "Qee qhov qauv peb khaws cia tsis tuaj yeem hloov pauv tau," Neil hais.

"Peb tab tom tham txog kev npaj cov qe ntshav dawb los ntawm cov kab mob tsis tshua muaj, kev sim tshuaj ntsuam xyuas, thiab lwm yam ntaub ntawv uas tseem ceeb rau kev tshawb fawb. Cov qauv no tsis yog siv hauv chav kuaj xwb; lawv tau koom nrog cov neeg koom tes thoob ntiaj teb, ua rau lawv txoj kev ncaj ncees yog qhov tseem ceeb heev. Kev muaj peev xwm ntawm cov hlwb no yog txhua yam. Yog tias lawv tsis khaws cia zoo, kev tshawb fawb lawv txhawb nqa tuaj yeem ntseeg tau tias yog vim li cas peb xav tau. system, peb muaj kev thaj yeeb nyab xeeb Peb tuaj yeem tshawb xyuas qhov kub thiab txias txhua lub sijhawm, thiab yog tias peb tau kuaj xyuas, peb tuaj yeem ntseeg tau tias txhua yam tau khaws cia kom raug.

 Txhim kho sustainability thiab nqi efficiency

Kev taw qhia ntawm biobank tshiab tau txo qis hauv chav kuaj cov kua nitrogen noj, txiav nws kaum npaug. Neil piav qhia tias "Txhua lub tank qub tau tuav txog 125 litres, yog li kev sib sau ua ke tau ua qhov sib txawv loj," Neil piav qhia. "Tam sim no peb tab tom siv ib feem ntawm cov nitrogen uas peb tau ua ua ntej, thiab qhov ntawd yog qhov yeej tseem ceeb ntawm nyiaj txiag thiab ib puag ncig."

Nrog tsawg dua nitrogen xa khoom, cov pa roj carbon emissions tau raug txo, txhawb lub lab lub hom phiaj sustainability. "Nws tsis yog hais txog nitrogen xwb," Neil ntxiv. "Kev xa khoom tsawg dua txhais tau tias cov tsheb thauj khoom tsawg dua ntawm txoj kev, thiab siv zog tsawg dua los tsim cov nitrogen hauv thawj qhov chaw." Cov kev txhim kho no tseem ceeb heev uas Imperial tau txais txiaj ntsig kev ruaj ntseg los ntawm ob qho tib si LEAF thiab My Green Lab hauv kev lees paub ntawm nws txoj kev siv zog.

Xaus

Haier Biomedical's cryogenic biobank tau hloov pauv ICL lub peev xwm khaws cia, txhim kho kev ua haujlwm, kev nyab xeeb thiab kev ruaj ntseg thaum txo cov nqi. Nrog kev ua tau zoo dua, txhim kho cov qauv kev ruaj ntseg thiab txo qhov cuam tshuam ib puag ncig, kev txhim kho tau ua tiav zoo.

Cov txiaj ntsig ntawm qhov project

1.LN₂noj tau txo los ntawm 90%, txiav nqi thiab emissions

2.Kev soj ntsuam zoo dua qub thiab kev ua raws HTA

3.Safer vapour-phase cia rau cov kws tshawb fawb

4.Ua kom muaj peev xwm cia hauv ib qho system

5.Kev lees paub los ntawm cov khoom plig sustainability